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Fanconi syndrome

Definition

Fanconi syndrome is a disorder of the kidney tubes in which certain substances normally absorbed into the bloodstream by the kidneys are released into the urine instead.

Alternative Names

De Toni-Fanconi syndrome

Causes

Fanconi syndrome can be caused by faulty genes, or it may result later in life due to kidney damage. Sometimes the cause of Fanconi syndrome is unknown.

Common causes of Fanconi syndrome in children are genetic defects that affect the body's ability to break down certain compounds such as:

Cystinosis is the most common cause of Fanconi syndrome in children.

Other causes in children include:

  • Exposure to heavy metals such as lead, mercury, or cadmium
  • Lowe's disease, a rare genetic disorder of the eyes, brain, and kidneys
  • Wilson's disease

In adults, Fanconi syndrome can be caused by various things that damage the kidneys, including:

Symptoms

  • Passing large amounts of urine, which can lead to dehydration
  • Bone pain
  • Weakness

Exams and Tests

Laboratory tests may show that too much of the following substances may be lost in the urine:

Loss of these substances can lead to a variety of problems. Further tests and a physical exam may show signs of:

Treatment

Many different diseases can cause Fanconi syndrome. The underlying cause and its symptoms should be treated as appropriate.

Outlook (Prognosis)

The prognosis depends on the underlying disease.

When to Contact a Medical Professional

Call your health care provider if you have dehydration or muscle weakness.

References

Seifter JL. Potassium disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 118.

Review Date: 3/9/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Herbert Y. Lin, MD, PHD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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