If you are currently being treated with any of the following medications, you should not use glucosamine or make any adjustments to your medications without first talking to your health care provider.

Nonsteroidal anti-inflammatory drugs (NSAIDs) -- Glucosamine may increase the anti-inflammatory activity of NSAIDs such as ibuprofen (Motrin or Advil). This interaction may result in the need for lower doses of these medications.

Blood sugar lowering medications or insulin -- Glucosamine may alter the need for blood sugar lowering medications and insulin. Check with your health care provider before taking glucosamine supplements if you have diabetes and require blood sugar lowering medicines or insulin.