Acetaminophen: Substrate (minor) of CYP1A2, 2A6, 2C8/9, 2D6, 2E1, 3A4; Inhibits CYP3A4 (weak)
Diphenhydramine: Inhibits CYP2D6 (moderate)
Also see individual agents.
[DSC] = Discontinued product Caplet: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg
Excedrin® P.M.: Acetaminophen 500 mg and diphenhydramine citrate 38 mg [contains benzoic acid]
Legatrin PM®: Acetaminophen 500 mg and diphenhydramine hydrochloride 50 mg
Percogesic® Extra Strength: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg
Tylenol® PM Extra Strength: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg
Tylenol® Severe Allergy: Acetaminophen 500 mg and diphenhydramine hydrochloride 12.5 mg
Gelcap (Tylenol® PM Extra Strength): Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg [contains benzyl alcohol]
Geltab: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg
Excedrin® P.M.: Acetaminophen 500 mg and diphenhydramine citrate 38 mg [contains benzoic acid]
Tylenol® PM Extra Strength: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg [contains benzyl alcohol]
Powder for oral solution (Goody's PM® Powder): Acetaminophen 500 mg and diphenhydramine citrate 38 mg
Tablet: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg
Anacin® PM Aspirin-Free [DSC], Tylenol® PM Extra Strength: Acetaminophen 500 mg and diphenhydramine hydrochloride 25 mg
Excedrin® P.M.: Acetaminophen 500 mg and diphenhydramine citrate 38 mg [contains benzoic acid]
Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage,"Ann Intern Med, 1977, 87(3):299-301.
Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine,"J Clin Pharmacol, 1983, 23(1):37-43.
Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol,"Ann Intern Med, 1980, 92(4):511.
Mokhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critical Care: Part II: Specific Poisonings,"Chest, 2003, 123(3):897-922.
