Acetaminophen: Substrate (minor) of CYP1A2, 2A6, 2C8/9, 2D6, 2E1, 3A4; Inhibits CYP3A4 (weak) Also see individual agents.
Oral: Analgesic: Based on acetaminophen component:
Children: 10-15 mg/kg/dose every 4-6 hours as needed; do not exceed 5 doses in 24 hours
Adults: 325-650 mg every 4-6 hours as needed; do not exceed 4 g/day
Decongestant: Based on pseudoephedrine component:
Children:
2-6 years: 15 mg every 4 hours; do not exceed 90 mg/day
6-12 years: 30 mg every 4 hours; do not exceed 180 mg/day
Children >12 years and Adults: 60 mg every 4 hours; do not exceed 360 mg/day
Product labeling:
Alka-Seltzer Plus® Cold and Sinus:
Children 6-12 years: 1 dose with water every 4 hours (maximum: 4 doses/24 hours)
Adults: 2 doses with water every 4 hours (maximum: 4 doses/24 hours)
Children's Tylenol® Sinus: Children:
Liquid:
2-5 years (24-47 lb): 1 teaspoonful every 4-6 hours (maximum: 4 doses/24 hours)
6-11 years (48-95 lb): 2 teaspoonfuls every 4-6 hours (maximum: 4 doses/24 hours)
Tablet, chewable:
2-5 years (24-47 lb): 2 tablets every 4-6 hours (maximum: 4 doses/24 hours)
6-11 years (48-95 lb): 4 tablets every 4-6 hours (maximum: 4 doses/24 hours)
Sinutab® Sinus: Children >12 years and Adults: 2 doses every 6 hours (maximum: 8 doses/24 hours)
Caplet:
Ornex®: Acetaminophen 325 mg and pseudoephedrine hydrochloride 30 mg
Genapap™ Sinus Maximum Strength, Mapap Sinus Maximum Strength, Ornex® Maximum Strength, Sudafed® Sinus Headache, Tylenol® Sinus Day Non-Drowsy: Acetaminophen 500 mg and pseudoephedrine hydrochloride 30 mg
Capsule, liquid (Alka-Seltzer Plus® Cold and Sinus, Sudafed® Sinus and Cold): Acetaminophen 325 mg and pseudoephedrine hydrochloride 30 mg
Gelcap (Tylenol® Sinus Day Non-Drowsy): Acetaminophen 500 mg and pseudoephedrine hydrochloride 30 mg
Geltab (Mapap Sinus Maximum Strength, Tylenol® Sinus Day Non-Drowsy): Acetaminophen 500 mg and pseudoephedrine hydrochloride 30 mg
Liquid, oral drops (Infants Tylenol® Cold): Acetaminophen 80 mg/0.8 mL and pseudoephedrine 7.5 mg/0.8 mL [contains sodium benzoate; bubble gum flavor]
Suspension (Children's Tylenol® Sinus): Acetaminophen 160 mg and pseudoephedrine hydrochloride 15 mg/5 mL [contains sodium benzoate; fruit flavor]
Tablet:
Cetafen Cold®, Medi-Synal, Sinus-Relief: Acetaminophen 325 mg and pseudoephedrine hydrochloride 30 mg
Sinutab® Sinus, Sudafed® Sinus Headache, SudoGest Sinus: Acetaminophen 500 mg and pseudoephedrine hydrochloride 30 mg
Mokhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critical Care: Part II: Specific Poisonings,"Chest, 2003, 123(3):897-922.
