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Pronunciation(eye byoo PROE fen)
U.S. Brand NamesAdvil® [OTC]; Advil® Children's [OTC]; Advil® Infants' [OTC]; Advil® Junior [OTC]; Advil® Migraine [OTC]; Genpril® [OTC]; Haltran® [OTC] [DSC]; Ibu-200 [OTC]; I-Prin [OTC]; Menadol® [OTC]; Midol® Maximum Strength Cramp Formula [OTC]; Motrin®; Motrin® Children's [OTC]; Motrin® IB [OTC]; Motrin® Infants' [OTC]; Motrin® Junior Strength [OTC]; Motrin® Migraine Pain [OTC]; Proprinal [OTC]; Ultraprin [OTC]
Synonymsp-Isobutylhydratropic Acid
Generic AvailableYes: Caplet, suspension, tablet
Canadian Brand NamesAdvil®; Apo-Ibuprofen®; Motrin®; Motrin® (Children's); Motrin® IB; Novo-Profen; Nu-Ibuprofen
UseInflammatory diseases and rheumatoid disorders including juvenile rheumatoid arthritis, mild to moderate pain, fever, dysmenorrhea
Use - DentalManagement of pain and swelling
Use - Unlabeled/InvestigationalCystic fibrosis, gout, ankylosing spondylitis, acute migraine headache
Pregnancy Risk FactorB/D (3rd trimester)
LactationEnters breast milk/use caution (AAP rates "compatible")
ContraindicationsHypersensitivity to ibuprofen, any component of the formulation, aspirin, or other NSAIDs; patients with "aspirin triad" (bronchial asthma, aspirin intolerance, rhinitis); pregnancy (3rd trimester)
Warnings/PrecautionsFatal asthmatic and anaphylactoid reactions have occurred in patients with "aspirin triad." Use with caution in patients with CHF, hypertension, dehydration, decreased renal or hepatic function, history of GI disease (bleeding, ulcers, or previous GI symptoms with NSAID use), or those receiving anticoagulants and/or corticosteroids. Use lowest effective dose for shortest period possible; bleeding risk has been correlated to dose and duration of therapy. Gastrointestinal bleeding may occur without prior symptoms of gastrointestinal irritation. Elderly are at a high risk for adverse effects from NSAIDs. As many as 60% of elderly can develop peptic ulceration and/or hemorrhage asymptomatically. Use of NSAIDs can compromise existing renal function especially when Clcr<30 mL/minute. CNS adverse effects such as confusion, agitation, and hallucination are generally seen in overdose or high-dose situations; however, elderly may demonstrate these adverse effects at lower doses than younger adults. Do not exceed 3200 mg/day. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.
OTC labeling: Recommended dosages should not be exceeded, due to an increased risk of GI bleeding. Consuming  3 alcoholic beverages/day may increase the risk of GI bleeding. When used for self-medication, patients should be instructed to contact healthcare provider if used for fever lasting >3 days or for pain lasting >10 days in adults or >3 days in children. Do not use for >2 days or administer to children <3 years of age unless instructed by healthcare provider. Consult healthcare provider whe sore throat pain is severe, persistent, or accompnaied by fever, headache, nausea, and/or vomiting.
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Adverse Reactions1% to 10%:
Cardiovascular: Edema (1% to 3%)
Central nervous system: Dizziness (3% to 9%), headache (1% to 3%), nervousness (1% to 3%)
Dermatologic: Itching (1% to 3%), rash (3% to 9%)
Endocrine & metabolic: Fluid retention (1% to 3%)
Gastrointestinal: Dyspepsia (1% to 3%), vomiting (1% to 3%), abdominal pain/cramps/distress (1% to 3%), heartburn (3% to 9%), nausea (3% to 9%), diarrhea (1% to 3%), constipation (1% to 3%), flatulence (1% to 3%), epigastric pain (3% to 9%), appetite decreased (1% to 3%)
Otic: Tinnitus (3% to 9%)
<1%: Acute renal failure, agranulocytosis, allergic rhinitis, alopecia, amblyopia, anaphylaxis, arrhythmia, aplastic anemia, aseptic meningitis, azotemia, blurred vision, bone marrow suppression, bronchospasm, CHF, confusion, conjunctivitis, creatinine clearance decreased, cystitis, depression, drowsiness, dry eyes, duodenal ulcer, edema, emotional lability, eosinophilia, epistaxis, erythema multiforme, gastric ulcer, gastritis, GI bleed, GI hemorrhage, GI ulceration, hallucinations, hearing decreased, hematuria, hematocrit decreased, hemoglobin decreased, hemolytic anemia, hepatitis, hypertension, inhibition of platelet aggregation, insomnia, jaundice, liver function tests abnormal, leukopenia, melena, neutropenia, palpitation, pancreatitis, peripheral neuropathy, photosensitivity, polydipsia, polyuria, Stevens-Johnson syndrome, tachycardia, thrombocytopenia, toxic amblyopia, toxic epidermal necrolysis, urticaria, vesiculobullous eruptions, vision changes
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Overdosage/ToxicologySymptoms of overdose include apnea, metabolic acidosis, coma, nystagmus, seizures, leukocytosis, and renal failure. Management of NSAID intoxication is supportive and symptomatic. Since many NSAIDs undergo enterohepatic cycling, multiple doses of charcoal may be needed to reduce the potential for delayed toxicities.
Drug InteractionsSubstrate (minor) of CYP2C8/9, 2C19; Inhibits CYP2C8/9 (strong) ACE inhibitors: Antihypertensive effects may be decreased by concurrent therapy with NSAIDs; monitor blood pressure.
Angiotensin II antagonists: Antihypertensive effects may be decreased by concurrent therapy with NSAIDs; monitor blood pressure.
Anticoagulants (warfarin, heparin, LMWHs) in combination with NSAIDs can cause increased risk of bleeding.
Antiplatelet drugs (ticlopidine, clopidogrel, aspirin, abciximab, dipyridamole, eptifibatide, tirofiban) can cause an increased risk of bleeding.
Corticosteroids: May increase the risk of GI ulceration; avoid concurrent use
Cyclosporine: NSAIDs may increase serum creatinine, potassium, blood pressure, and cyclosporine levels; monitor cyclosporine levels and renal function carefully.
CYP2C8/9 substrates: Ibuprofen may increase the levels/effects of CYP2C8/9 substrates. Example substrates include amiodarone, fluoxetine, glimepiride, glipizide, nateglinide, phenytoin, pioglitazone, rosiglitazone, sertraline, and warfarin.
Hydralazine's antihypertensive effect is decreased; avoid concurrent use
Lithium levels can be increased; avoid concurrent use if possible or monitor lithium levels and adjust dose. Sulindac may have the least effect. When NSAID is stopped, lithium will need adjustment again.
Loop diuretics efficacy (diuretic and antihypertensive effect) is reduced. Indomethacin reduces this efficacy, however, it may be anticipated with any NSAID.
Methotrexate: Severe bone marrow suppression, aplastic anemia, and GI toxicity have been reported with concomitant NSAID therapy. Avoid use during moderate or high-dose methotrexate (increased and prolonged methotrexate levels). NSAID use during low-dose treatment of rheumatoid arthritis has not been fully evaluated; extreme caution is warranted.
Warfarin's INRs may be increased by piroxicam. Other NSAIDs may have the same effect depending on dose and duration. Monitor INR closely. Use the lowest dose of NSAIDs possible and for the briefest duration. May alter the anticoagulant effects of warfarin; concurrent use with other antiplatelet agents or anticoagulants may increase risk of bleeding.
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Ethanol/Nutrition/Herb InteractionsEthanol: Avoid ethanol (may enhance gastric mucosal irritation).
Food: Ibuprofen peak serum levels may be decreased if taken with food.
Herb/Nutraceutical: Avoid cat's claw, dong quai, evening primrose, feverfew, garlic, ginger, ginkgo, red clover, horse chestnut, green tea, ginseng (all have additional antiplatelet activity).
Mechanism of ActionInhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase, which results in decreased formation of prostaglandin precursors
Pharmacodynamics/KineticsOnset of action: Analgesic: 30-60 minutes; Anti-inflammatory:  7 days
Peak effect: 1-2 weeks
Duration: 4-6 hours
Absorption: Oral: Rapid (85%)
Protein binding: 90% to 99%
Metabolism: Hepatic via oxidation
Half-life elimination: 2-4 hours; End-stage renal disease: Unchanged
Time to peak: ~1-2 hours
Excretion: Urine (1% as free drug); some feces
DosageOral: Children:
Antipyretic: 6 months to 12 years: Temperature <102.5°F (39°C): 5 mg/kg/dose; temperature >102.5°F: 10 mg/kg/dose given every 6-8 hours (maximum daily dose: 40 mg/kg/day)
Juvenile rheumatoid arthritis: 30-50 mg/kg/24 hours divided every 8 hours; start at lower end of dosing range and titrate upward (maximum: 2.4 g/day)
Analgesic: 4-10 mg/kg/dose every 6-8 hours
Cystic fibrosis (unlabeled use): Chronic (>4 years) twice daily dosing adjusted to maintain serum levels of 50-100 mcg/mL has been associated with slowing of disease progression in younger patients with mild lung disease
OTC labeling (analgesic, antipyretic):
Children 6 months to 11 years: See table; use of weight to select dose is preferred; doses may be repeated every 6-8 hours (maximum: 4 doses/day)
Children 12 years: 200 mg every 4-6 hours as needed (maximum: 1200 mg/24 hours)
Ibuprofen DosingWeight
(lb) | Age | Dosage
(mg) | | 12-17 | 6-11 mo | 50 | | 18-23 | 12-23 mo | 75 | | 24-35 | 2-3 y | 100 | | 35-47 | 4-5 y | 150 | | 48-59 | 6-8 y | 200 | | 60-71 | 9-10 y | 250 | | 72-95 | 11 y | 300 |
Adults:
Inflammatory disease: 400-800 mg/dose 3-4 times/day (maximum dose: 3.2 g/day)
Analgesia/pain/fever/dysmenorrhea: 200-400 mg/dose every 4-6 hours (maximum daily dose: 1.2 g, unless directed by physician)
OTC labeling (analgesic, antipyretic): 200 mg every 4-6 hours as needed (maximum: 1200 mg/24 hours)
Dosing adjustment/comments in severe hepatic impairment: Avoid use
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AdministrationAdminister with food
Monitoring ParametersCBC; occult blood loss and periodic liver function tests; monitor response (pain, range of motion, grip strength, mobility, ADL function), inflammation; observe for weight gain, edema; monitor renal function (urine output, serum BUN and creatinine); observe for bleeding, bruising; evaluate gastrointestinal effects (abdominal pain, bleeding, dyspepsia); mental confusion, disorientation; with long-term therapy, periodic ophthalmic exams
Reference RangePlasma concentrations >200 mcg/mL may be associated with severe toxicity
Dietary ConsiderationsShould be taken with food. Chewable tablets may contain phenylalanine; amount varies by product, consult manufacturers labeling.
Patient EducationIf self-administered, use exactly as directed; do not increase dose or frequency. Adverse reactions can occur with overuse. Consult your prescriber before use if you have hypertension or heart failure. Do not take longer than 3 days for fever, or 10 days for pain without consulting medical advisor. Take with food or milk. While using this medication, do not use alcohol, excessive amounts of vitamin C, or salicylate containing foods (curry powder, prunes, raisins, tea, or licorice), other prescription or OTC medications containing aspirin or salicylate, or other NSAIDs without consulting prescriber. Maintain adequate hydration (2-3 L/day of fluids) unless instructed to restrict fluid intake. You may experience nausea, vomiting, gastric discomfort (frequent mouth care, small, frequent meals, chewing gum, sucking lozenges may help). GI bleeding, ulceration, or perforation can occur with or without pain. Stop taking medication and report ringing in ears; persistent cramping or stomach pain; unresolved nausea or vomiting; respiratory difficulty or shortness of breath; unusual bruising or bleeding (mouth, urine, stool); skin rash; unusual swelling of extremities; chest pain; or palpitations. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. This drug should not be used in the 3rd trimester of pregnancy. Consult prescriber if breast-feeding.
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Anesthesia and Critical Care Concerns/Other ConsiderationsThe 2002 ACCM/SCCM guidelines for analgesia (critically-ill adult) suggest that NSAIDs may be used in combination with opioids in select patients for pain management. Concern about adverse events (increased risk of renal dysfunction, altered platelet function and gastrointestinal irritation) limits its use in patients who have other underlying risks for these events. In short-term use, NSAIDs vary considerably in their effect on blood pressure. When NSAIDs are used in patients with hypertension, appropriate monitoring of blood pressure responses should be completed and the duration of therapy, when possible, kept short. The use of NSAIDs in the treatment of patients with congestive heart failure may be associated with an increased risk for fluid accumulation and edema. May precipitate renal failure in dehydrated patients.
Cardiovascular ConsiderationsIn short-term use, NSAIDs vary considerably in their effect on blood pressure. A recent meta-analysis (see References) showed that indomethacin and naproxen had the largest effect on blood pressure. Other NSAIDs, including piroxicam, ibuprofen, and sulindac had less of an effect. Ibuprofen combined with captopril or losartan may attenuate the antihypertensive effects of ACE inhibition or receptor blockade on sitting or 24-hour ambulatory diastolic blood pressure. When NSAIDs are used in patients with hypertension, appropriate monitoring of blood pressure responses should be completed and the duration of therapy, when possible, kept short. The use of NSAIDs in the treatment of patients with congestive heart failure may be associated with an increased risk for fluid accumulation and edema. One study showed that NSAID use in elderly patients had an increased risk of hospitalization for heart failure. This study gives compelling reasons to avoid or limit the use of NSAIDs in patients with congestive heart failure, particularly in the elderly population.
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Dental Health: Effects on Dental TreatmentNSAID formulations are known to reversibly decrease platelet aggregation via mechanisms different than observed with aspirin. The dentist should be aware of the potential of abnormal coagulation. Caution should also be exercised in the use of NSAIDs in patients already on anticoagulant therapy with drugs such as warfarin (Coumadin®).
Dental Health: Vasoconstrictor/Local Anesthetic PrecautionsNo information available to require special precautions
Dental CommentPreoperative use of ibuprofen at a dose of 400-600 mg every 6 hours 24 hours before the appointment decreases postoperative edema and hastens healing time.
Mental Health: Effects on Mental StatusDrowsiness and dizziness are common; may cause nervousness; may rarely cause insomnia, confusion, hallucinations, or depression
Mental Health: Effects on Psychiatric TreatmentMay rarely cause agranulocytosis; use caution with clozapine and carbamazepine; may decrease lithium clearance resulting in an increase in serum lithium levels and potential lithium toxicity; monitor serum lithium levels
Dosage Forms[DSC] = Discontinued product Caplet: 200 mg [OTC]
Advil®: 200 mg [contains sodium benzoate]
Ibu-200, Menadol®, Motrin® IB, Motrin® Migraine Pain: 200 mg
Motrin® Junior Strength: 100 mg [contains tartrazine]
Capsule, liqui-gel:
Advil®: 200 mg
Advil® Migraine: 200 mg [solubilized ibuprofen]
Gelcap:
Advil®: 200 mg
Motrin® IB: 200 mg [contains benzyl alcohol]
Suspension, oral: 100 mg/5 mL (5 mL, 120 mL, 480 mL)
Advil® Children's: 100 mg/5 mL (60 mL, 120 mL) [contains sodium benzoate; blue raspberry, fruit, and grape flavors]
Motrin® Children's: 100 mg/5 mL (60 mL, 120 mL) [contains sodium benzoate; berry, dye free berry, bubble gum, and grape flavors]
Suspension, oral drops: 40 mg/mL (15 mL)
Advil® Infants': 40 mg/mL (15 mL) [contains sodium benzoate; fruit and grape flavors]
Motrin® Infants': 40 mg/mL (15 mL, 30 mL) [contains sodium benzoate; berry and dye-free berry flavors]
Tablet: 200 mg [OTC], 400 mg, 600 mg, 800 mg
Advil®: 200 mg [contains sodium benzoate]
Advil® Junior: 100 mg [contains sodium benzoate; coated tablets]
Genpril®, Haltran® [DSC], I-Prin, Midol® Maximum Strength Cramp Formula, Motrin® IB, Proprinal, Ultraprin: 200 mg
Motrin®: 400 mg, 600 mg, 800 mg
Tablet, chewable:
Advil® Children's: 50 mg [contains phenylalanine 2.1 mg; fruit and grape flavors]
Advil® Junior: 100 mg [contains phenylalanine 2.1 mg; fruit and grape flavors]
Motrin® Children's: 50 mg [contains phenylalanine 1.4 mg; orange flavor]
Motrin® Junior Strength: 100 mg [contains phenylalanine 2.1 mg; grape and orange flavors]
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ReferencesBerde C, Ablin A, Glazer J, et al, "American Academy of Pediatrics Report of the Subcommittee on Disease-Related Pain in Childhood Cancer,"Pediatrics, 1990, 86(5 Pt 2):818-25.
Brewer EJ, "Nonsteroidal Anti-inflammatory Agents,"Arthritis Rheum, 1977, 20(2):513-25.
Brooks PM and Day RO, "Nonsteroidal Anti-inflammatory Drugs - Differences and Similarities,"N Engl J Med, 1991, 324(24):1716-25.
Castillo M, Lam, YW, Dooley MA, et al, "Disposition and Covalent Binding of Ibuprofen and its Acyl Glucuronide in the Elderly,"Clin Pharmacol Ther, 1995, 57(6):636-44.
Clinch D, Banerjee AK, and Ostick G, "Absence of Abdominal Pain in Elderly Patients With Peptic Ulcer,"Age Ageing, 1984, 13(2):120-3.
Clive DM and Stoff JS, "Renal Syndromes Associated With Nonsteroidal Anti-inflammatory Drugs,"N Engl J Med, 1984, 310(9):563-72.
Conlin P, Moore T, Swartz S, et al, "Effect of Indomethacin on Blood Pressure Lowering by Captopril and Losartan in Hypertensive Patients,"Hypertension, 2000, 36(3):461-5.
Court H and Volans GN, "Poisoning After Overdose With Nonsteroidal Anti-inflammatory Drugs,"Adverse Drug React Acute Poisoning Rev, 1984, 3(1):1-21.
Davies NM, "Clinical Pharmacokinetics of Ibuprofen. The First 30 Years,"Clin Pharmacokinet, 1998, 34(2):101-54.
Dionne RA, "New Approaches to Preventing and Treating Postoperative Pain,"J Am Dent Assoc, 1992, 123(6):26-34.
"Drugs for Pain,"Med Lett Drugs Ther, 2000, 42(1085):73-8.
Gobetti JP, "Controlling Dental Pain,"J Am Dent Assoc, 1992, 123(6):47-52.
Graham DY, "Prevention of Gastroduodenal Injury Induced by Chronic Nonsteroidal Anti-inflammatory Drug Therapy,"Gastroenterology, 1989, 96(2 Pt 2 Suppl):675-81.
Gurwitz JH, Avorn J, Ross-Degnan D, et al, "Nonsteroidal Anti-Inflammatory Drug-Associated Azotemia in the Very Old,"JAMA, 1990, 264(4):471-5.
Hall AH, Smolinske SC, Conrad FL, et al, "Ibuprofen Overdose: 126 Cases,"Ann Emerg Med, 1986, 15(11):1308-13.
Hawkey CJ, Karrasch JA, Szczepañski L, et al, "Omeprazole Compared With Misoprostrol for Ulcers Associated With Nonsteroidal Anti-inflammatory Drugs,"N Engl J Med, 1998, 338(11):727-34.
Heerdink ER, Leufkens HG, Herings RM, et al, "NSAIDs Associated With Increased Risk of Congestive Heart Failure in Elderly Patients Taking Diuretics,"Arch Intern Med, 1998, 158(10):1108-12.
Hoppmann RA, Peden JG, and Ober SK, "Central Nervous System Side Effects of Nonsteroidal Anti-inflammatory Drugs. Aseptic Meningitis, Psychosis, and Cognitive Dysfunction,"Arch Intern Med, 1991, 151(7):1309-13.
Jacobi J, Fraser GL, Coursin DB, et al, "Clinical Practice Guidelines for the Sustained Use of Sedatives and Analgesics in the Critically Ill Adult,"Crit Care Med, 2002, 30(1):119-41. Available at: http://www.sccm.org/pdf/sedatives.pdf. Accessed August 2, 2003.
Kauffman RE and Nelson MV, "Effect of Age on Ibuprofen Pharmacokinetics and Antipyretic Response,"J Pediatr, 1992, 121(6):969-73.
Keller KH, "Hypoprothrombinemia Without Hepatocellular Injury in Ibuprofen Overdose,"Clin Toxicol, 1995, 33(5):492-3.
Kim J, Gazarian M, Verjee Z, et al, "Acute Renal Insufficiency in Ibuprofen Overdose,"Pediatr Emerg Care, 1995, 11(2):107-8.
Knodel LC, "Preventing NSAID-Induced Ulcers: The Role of Misoprostol,"Consult Pharm, 1989, 4:37-41.
Konstan MW, Byard PJ, Hoppel CL, et al, "Effect of High-Dose Ibuprofen in Patients With Cystic Fibrosis,"N Engl J Med, 1995, 332(13):848-54.
Konstan MW, Krenicky JE, Finney MR, et al, "Effect of Ibuprofen on Neutrophil Migration in vivo in Cystic Fibrosis and Healthy Subjects,"J Pharmacol Exp Ther, 2003, 306(3):1086-91.
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McElwee NE, Veltri JC, Bradford DC, et al, "A Prospective, Population-Based Study of Acute Ibuprofen Overdose: Complications Are Rare and Routine Serum Levels are Not Warranted,"Ann Emerg Med, 1990, 19(6):657-62.
Mixter CG 3d, Meeker LD, and Gavin TJ, "Preemptive Pain Control in Patients Having Laparoscopic Hernia Repair: A Comparison of Ketorolac and Ibuprofen,"Arch Surg, 1998, 133(4):432-7.
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International Brand NamesACT-3® (AU); Actifen® (NL); Actiprofen® (AU, BR); Adco-Ibuprofen® (ZA); Adex® (IL); Adulfen Lysine® (BE); Advil® (BE, BR, CA, CH, CL, CO, EC, ES, FR, HU, IE, IL, MX, NL, PL, RO, YU, ZA); Ainex® (MX); Aktren® (AT, DE, PL); Algiasdin® (ES); Algidol® (MX); Algidrin® (ES); Algifen® (TR); Algifor® (CH); Algifor-L® (CH); Algioprofen® (AR); Algofen® (IT); Alindrin® (SE); Alogesia® (ES); Altior® (ES); Altran Pediatrico® (HN); Ambufen® (TH); Anafen® (NZ); Analgin® (DE); Anbifen® (TH); Anco® (DE); Antalgil® (IT); Antalisin® (IT); Antarène® (FR); Antidol® (RO); Antiflam® (BD); Apain® (DK); Apo-Ibuprofen® (CA, CZ, SG); Aprofen® (TH); Arafa® (BD); Ardinex® (SE); Arfen® (IT, PT); Arthrifen® (ID); Arthrofen® (GB); Artofen® (CH, IL); Artril® (BR, TR); Astodol 800® (CL); Astodol® (CL); Avallone® (AT); Babypiril® (ES); Bediatil® (CL); Bediatil Forte® (CL); Benotrin® (BR); Betagesic® (ZA); Betaprofen® (ZA); Bifen® (SG); Biophen® (TR); Bladex® (CL); Bolinet® (PL); Bonifen® (HR, RU, SI); Brafeno® (AR); Brufen® (AT, AU, BE, CH, CZ, DK, EG, FI, FR, GB, HK, HR, IN, IT, JO, KW, LB, LU, NL, NO, NZ, PT, RU, SE, SY, TH, TR, YU, ZA); Brufen Retard® (FI, GB, IE, NO, SE); Brumed (TH); Bruprin® (TH); Brusil® (TH); Buburone® (JP); Bufect® (ID); Bufigen® (IE); Bumed® (TH); Buprex® (EC); Buprophar® (BE); Burana-Caps® (FI); Burana® (FI, RU); Buscofen® (IT); Butidiona® (AR); Calide® (CL); Calmidol® (CO); Calmine® (IT); Calprofen® (GB); Cefen Junior® (TH); Cefen® (TH); Chemofen® (BD); Children's Advil® (IL); Children's Motrin® (ID); Cibalgina Due Fast® (IT); Citalgan® (MX); Contraneural® (DE); Copiron® (AR); Coprofen® (TH); Cuprofen® (GB); Cuprofen Ibuprofen® (GB); Dalsy® (BR, ES, HR); Danilon® (BR); Days® [tabs] (MX); Decontractil New® (BE); Deep Relief® (GB); Defensol® (CL); Deprofen® (BD); Dexit® (FI); Diantal® (CO); Diantal Suspension Pediatrica® (CO); Dibufen® (MX); Diltix® (ES); Diprodol® (MX); Dismenol® (AT, CH, DE, LU); Diverin® (HR, PL, SI); Doctril® (ES); Dofen® (ID); Dol® (CO); Dolgit® (AT, BE, CZ, DE, EG, FR, HU, LU, PL, RU, SI, TR); Dolgit Milinda® (DE); Dolibu® (AT); Dolobeneurin® (AR); Dolocyl® (CH, IT, PT); Dolo-Dismenol® (CH); Dolodoc® (DE); Dolofast® (IT); Dolofen-F® (ID); Dolofin® (BE, LU); Dolofort® (AT); Dolomo-IBU® (DE); Dolo-Puren® (DE); Dolorac® (ES); Dolorin Tablet® (TR); Dolormin® (DE); Dolormin für Kinder® (DE); Dolorsyn® (AR); Dolorub® (CL); Dolo Sanol® (DE); Dolo-Spedifen® (CH); Doloxene® (CR, GT, HN, PA, SV); Dolten® (CO); Dolven® (TR); Doretrim® (BR); Dorival® (ES); Druisel® (AR); Duoflam® (IN); Duran® (TH); Ebufac® (GB); Ecoprofen® (CH); Edenil® (IT); Efficol® (EC); Epsilon® (BE); Espidifen® (ES); Esprenit® (DE); Esprenit Suppos® (DE); Esrufen® (BD); Eudorlin® (DE); Expanfen® (FR); Extrapan Ibuprofenum Gel® (BE); Faspic® (IT, RO); Febrifen® (CO); Febryn® (ID); Femapirin® (NL); Femen® (CO, EC); Feminalin® (ES); Fenbid® (GB, KW); Fenopine® (IE); Fenris® (ID); Fibraflex® (DE); Flamex® (BD); Flexafen® (MX); Frevac® (DO); Galprofen® (GB); Ganaprofene® (IT); Gelofeno® (ES); Gerofen® (TR); G-Fen® (TH); Gineflor® (IT); Ginenorm® (IT); Greatofen® (TH); Grefen® (CH); Gynofug® (DE); Gyno-Neuralgin® (DE); Heidi® (TH); Hémagène Tailleur® (FR); H.G. Iprofen® (EC); H-Loten® (CO); Huma-Ibuprofen® (HU); Huma-Profen® (HU); Ibalgin® (CZ); Iboflam® (ZA); Ibosure® (NL); Ibrofen® (TH); Ibu 1A Pharma® (DE); IBU-600 SR® (TR); Ibu AbZ® (DE); Ibu-acis® (DE); Ibu-Aliviol® (AR); ibu-Attritin® (DE); Ibu ben-u-ron® (DE); Ibubeta® (DE); Ibu bipharm® (LU); Ibucler® (AR); IBU® (CL, TH); Ibudolor® (AR, DE); Ibu Eu Rho® (DE); Ibu-Evanol® (AR); Ibufabra® (AR); Ibufac® (TH); Ibufem® (AT); Ibufen® (AT, ID, IL, PL, SG, TR); Ibufen-L® (CH); Ibufix® (AR); Ibuflam® (DE); Ibufran® (BR); Ibugan® (TH); Ibugel® (AT, GB, IE, LU); Ibugesic® (HK, IN, JO, KW, LB, MT, MY, RO); Ibu-Hemofarm® (YU); Ibu-Hemopharm® (DE); Ibuhexal® (DE, LU); Ibu KD® (DE); ibu KSK® (DE); Ibulan® (TH); Ibuleve® (IL, ZA); Ibuloid® (SG); Ibulös® (HU); Ibu L.U.T® (DE); Ibumac® (ES); Ibumax® (FI, ZA); Ibumed® (BE, ZA); Ibumerck® (DE); Ibumer® (CO); Ibumetin® (AT, DK, FI, NO, PL, RO, SE); Ibumousse® (GB); Ibum® (PL); Ibu Novalgina® (AR); Ibupar forte® (PL); Ibuphar® (BE); Ibuphlogont® (DE); Ibupirac® (AR, CL); Ibupiretas® (AR, CO); Ibuprofen AL® (CZ, DE); Ibuprofen Atid® (DE); Ibuprofen BC® (BE); Ibuprofen-Cophar® (CH); Ibuprofen® (DE, GB, HR, NO, PL, RO, RU, SI, YU); Ibuprofen Denk® (DE); Ibuprofene 200 Unifarm® (IT); Ibuprofene EG® (BE); Ibuprofene-Ethypharm® (LU); Ibuprofene-Eurogenerics® (LU); Ibuprofene Pliva® (IT); Ibuprofen-Farmacon® (HU); Ibuprofen Genericon® (AT); Ibuprofen Helvepharm® (CH); Ibuprofen Heumann® (DE); Ibuprofen Klinge® (DE); Ibuprofen Lannacher® (RU); Ibuprofen Lindo® (DE); Ibuprofen medphano® (DE); Ibuprofen Milinda® (DE); Ibuprofen-mp® (DE); Ibuprofen NM® (DK); Ibuprofen Nycomed® (RU); Ibuprofeno® (AR, BR, CL, EC); Ibuprofeno Biocrom® (AR); Ibuprofeno Bouzen® (AR); Ibuprofeno CBA® (AR); Ibuprofeno Drawer® (AR); Ibuprofeno Ecar® (CO); Ibuprofeno Esteve® (ES); Ibuprofeno Fada® (AR); Ibuprofeno Fecofar® (AR); Ibuprofeno Gemepe® (AR); Ibuprofeno Genfar® (EC); Ibuprofeno Ilab® (AR); Ibuprofeno Kern® (ES); Ibuprofeno Larjan® (AR); Ibuprofeno L.CH.® (CL); Ibuprofeno MK® (CO); Ibuprofeno Purissimus® (AR); Ibuprofeno Richet® (AR); Ibuprofeno Rovi® (ES); Ibuprofen PB® (DE); Ibuprofen Phoenix® (AR); Ibuprofen Polfa® (HU); Ibuprofen-ratiopharm® (FI); Ibuprofen Sandoz® (DE); Ibuprofen Stada® (DE); Ibuprofen UNP® (DK); ibuprofen von ct® (DE); Ibuprofen YSP® (SG); ibuprof von ct® (CZ, DE, LU); Ibuprom® (PL); Ibuprox® (ES); Ibu-ratiopharm® (DE); Iburen® (TH); Ibureumin® (DK); Iburex® (BD); Ibusal® (FI); Ibusan® (PL); Ibuscent® (CH); Ibusi® (AR); Ibusifar® (CH); Ibu-Slow® (BE); Ibuslow® (HK); Ibu-Slow® (LU); Ibusol Pediatrico® (AR); Ibuspray® (GB); Ibusumal® (AR); Ibutab® (BD); ibuTAD® (DE); ibuTAD S® (DE); Ibutop® (AT, BE, BG, DE, DK, EG, FR, HU, LU, PL, SI); Ibutop Cuprofen Ibuprofen® (GB); Ibutop Ralgex Ibuprofen® (GB); Ibuxin® (FI); Ibux® (NO); Ibuzidine® (AR); Ideben® (AR); ilvico grippal® (DE); Imbun® (AT, DE, LU); Inabrin® (BE, LU); Inadol® (ES); Infibu® (CO); Inflam® (BD); Intralgis® (FR); Inza® (ZA); Ipren® (DK, SE); Iproben® (CH); Irfen® (CH, CY, EG, JO, KW, LB); Isdibudol® (ES); Isdol® (ES); Jenaprofen® (DE); Junifen® (BE, ES, LU, TH); Kalma® (ES); Kesan® (AR); Kontagripp® (DE); Kontagripp Sandoz® (DE); Kratalgin® (AT); Lidifen® (GB); Lünodolor® (DE); Malafene® (BE, LU); Marcofen® (RO); Medibuprofen® (RO); Melabon Ibuprofen® (CH); Melfen® (IE); Mensoton® (DE); Migränin® (DE); Moment® (IT, PT); Motrax® (AR); Motrin® (BE, BR, CA, CL, CO, GB, ID, LU, MX); Motrin® (Children's) (CA); Motrin® IB (CA); Nefor® (DO); Neobrufen® (ES); Neofen® (HR); Neurofen® (BD); Niofen® (CL); Nodolfen® (ES); Nofena® (ID); Nofenal® (BE); Noflam® (BD); Norvectan® (ES); Novogeniol® (AR); Novogent® (DE); Novo-Profen® (CA); Nu-Ibuprofen (CA); Nureflex® (AT, FR, IT); Nurofen® (AT, BE, CH, CZ, DE, ES, FR, GB, HU, IE, IL, IT, LU, NL, PL, RO, RU, SG, TH, TR, ZA); Nurofen for children® (GB, IL); Nurofen Forte® (IL); Nurofen Junior® (DE); Nurofen-L® (CH); Nurofen pentru copii® (RO); Opsofen® (BD); Optalidon® (DE, LU); Optifen® (CH); Opturem® (DE); Orbiprofen® (GB); Orfen® (CO); Orgaprofen® (BD); Ostarin® (ID); Oxibut® (AR); Ozonol® (PT); Pabiprofen® (CZ); Paduden® (RO); Paraflex® (AR); Parsal® (DE); Pedea® (DE); Pediaprofen® (CL); Pedifen® (TR); Perofen® (CY, HK); Perskindol Ibuprofen akut® (CH); Perviam® (BE); Pfeil Zahnschmerz-Tabletten® (DE); P-Fen® (TH); Phamoprofen® (DE); Phorpain® (IE); Pippen® (TH); Pironal® (CL); Pocyl® (ES); Ponstil Mujer® (AR); Ponstin® (AR); Powerfen® (CO); Prifen® (ID); Proartinal® (MX); Probinex® (EC); Probufen® (TH); Profena® (TH); Profen® (BD, TR); Profeno® (TH); Profinal® (EC, RO); Proflex® (GB, IE); Proflex Pain Relief Gel® (GB); Proris® (ID); Protopen® (RO); Pyriped® (CL); Quadrax® (MX); Rafen® (AU); Ranfen® (ZA); ratioDolor® (AT, DE); Redufen® (CH); Relcofen® (GB); Relian® (NL); Remidol® (ES); Remofen® (JO, SY); Repozal® (TR); Reumafen® (BD); Reuprofen® (RO); Rhelafen® (ID); Rheumanox® (TH); Ribunal® (ID); Rimafen® (GB); Rodalgin® (CO); Rofen® (TR); Rolab-Ibuprofen® (ZA); Rumasian® (TH); Rumatifen® (TH); Rupan® (RO); Saetil® (ES); Salivia® (AR); Saridon® (CH); Schmerz-Dolgit® (DE, LU); Schufen® (TH); Serviprofen® (BD, CO); Seskafen® (TR); Shelrofen® (ID); Sindol® (AR); Sinedol Ibuprofen® (CH); Siprofen® (BE); Siyafen® (TR); Skelan IB® (TH); Smadol® (CO); Solfen® (IE); Solpaflex® (BG, CZ, HU, PL, RU, SI, YU); Solufen® (BE, CH, LU, PT); Solufen Lidose® (SG); Solvium® (ES); Sonotryl neue Formel® (CH); Spalt® (DE); Spalt Liqua® (DE); Spedifen® (CH, FR, HU); Spidifen® (BE); Staderm® (JP); Sugafen® (IN); Suprafen® (TR); Suprofen® (DO); Tabalon® (DE, GT, HN, MX, SV); Tabcin® (AT); Tempil® (DE); Teprix® (AR); Tispol IBU-DD® (DE); Tofen® (TH); Togal Ibuprofen® (DE); Togal N® (LU); Trauma-Dolgit® (DE, LU); Treupel Dolo Ibuprofen® (CH); Trifene® (PT); Tri-Profen® (AU); Trosifen® (CO); Ultrafen® (TR); Uniao Ibuprofeno® (BR); Unipron® (JP); Upfen® (FR, RO, YU); Upren® (TR); Urem® (DE); Urgo-Ibuprofen® (RO); Vesicum® (JP); Zafen® (IT, NL); Zahnschmerztabletten® (DE)
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