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Sulconazole

 Table of Contents > Drugs > Sulconazole     Print

Pronunciation
U.S. Brand Names
Synonyms
Generic Available
Canadian Brand Names
Use
Pregnancy Risk Factor
Lactation
Contraindications
Warnings/Precautions
Adverse Reactions
 
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Dosage
Patient Education
Dental Health: Effects on Dental Treatment
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dosage Forms
International Brand Names

Pronunciation

(sul KON a zole)

U.S. Brand Names

Exelderm®

Synonyms

Sulconazole Nitrate

Generic Available

No

Canadian Brand Names

Exelderm®

Use

Treatment of superficial fungal infections of the skin, including tinea cruris (jock itch), tinea corporis (ringworm), tinea versicolor, and possibly tinea pedis (athlete's foot, cream only)

Pregnancy Risk Factor

C

Lactation

Excretion in breast milk unknown/use caution

Contraindications

Hypersensitivity to sulconazole or any component of the formulation

Warnings/Precautions

Use with caution in nursing mothers; for external use only

Adverse Reactions

1% to 10%:

Dermatologic: Itching

Local: Burning, stinging, redness

Drug Interactions

Inhibits CYP1A2 (weak), 2A6 (weak), 2C8/9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak), 3A4 (weak)

No drug interaction data reported.

Mechanism of Action

Substituted imidazole derivative which inhibits metabolic reactions necessary for the synthesis of ergosterol, an essential membrane component. The end result is usually fungistatic; however, sulconazole may act as a fungicide in Candida albicans and parapsilosis during certain growth phases.

Pharmacodynamics/Kinetics

Absorption: Topical: ~8.7% percutaneously

Excretion: Primarily urine

Dosage

Adults: Topical: Apply a small amount to the affected area and gently massage once or twice daily for 3 weeks (tinea cruris, tinea corporis, tinea versicolor) to 4 weeks (tinea pedis).

Patient Education

For external use only; avoid contact with eyes; if burning or irritation develops, notify physician

Dental Health: Effects on Dental Treatment

No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

None reported

Mental Health: Effects on Psychiatric Treatment

None reported

Dosage Forms

Cream, as nitrate: 1% (15 g, 30 g, 60 g)

Solution, topical, as nitrate: 1% (30 mL)

International Brand Names

Exelderm® (CA, GB, HK, IE, TR); Fulcol® (DO); Minot® (AR); Myk 1® (BE, LU); Myk® (FR, NL)

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