Emergency Room Wait Times
Home > Healthy Living > Health Library > Organ Transplants: Antirejection Medicines
People who have had an organ transplant need antirejection medicines. This is because the immune system will try to destroy the new organ. These medicines are also called immunosuppressants. They weaken your immune system and decrease your body's ability to destroy your new organ. But they also decrease how well your body can fight infections, cancer, and other diseases.
Here are some of the medicines you may need to take. You may have to take other medicines to prevent infection or to control other health problems you have (like high blood pressure).
A high dose of a steroid medicine is given right before your transplant. It decreases your immune system's activity. It also reduces inflammation and prevents rejection. A high dose is usually continued for a few days after your surgery. Then the dosage is slowly reduced to the lowest dose that helps prevent rejection.
Taking steroid medicine for just a few days may cause short-term side effects. These include high blood pressure, weight gain, sleep problems, and anxiety. High doses can sometimes cause more severe side effects, such as extreme agitation, paranoia, psychosis, and hallucinations.
Using steroid medicine for a long time can cause glaucoma or steroid-induced diabetes.
These medicines include prednisone or methylprednisolone.
These medicines block the message that causes rejection. You probably will always need to take calcineurin inhibitors.
Side effects include high blood pressure, too much potassium in the blood (hyperkalemia), and kidney problems. These medicines can also cause nausea, vomiting, diarrhea, high cholesterol, tremors, and seizures.
These medicines include tacrolimus and cyclosporine.
These medicines prevent the immune cells from multiplying. They prevent your immune system from attacking and destroying the donor organ.
Common side effects can include nausea, anemia, high triglycerides, and intestinal upset.
These medicines include mycophenolate mofetil, azathioprine, and sirolimus.
These antibodies block the growth of immune cells that are responsible for rejection. They are used early after transplantation along with calcineurin inhibitors and antiproliferative agents.
These medicines include daclizumab, basiliximab, and rituximab.
These medicines deplete the body's immune cells for a short time. They are used in the hours and days right after your organ transplant. They prevent your body from rejecting the donor organ. They may also be used again if your body starts to reject the donor organ.
They are often used to reduce early use of calcineurin inhibitors, which can have serious side effects. Side effects of polyclonal antibodies include fever, itching, and joint pain.
These medicines include antithymocyte globulin-equine and antithymocyte globulin-rabbit.
Current as ofMarch 27, 2018
Author: Healthwise StaffMedical Review: E. Gregory Thompson, MD - Internal MedicineAdam Husney, MD - Family Medicine
Current as of:
March 27, 2018
Medical Review:E. Gregory Thompson, MD - Internal Medicine & Adam Husney, MD - Family Medicine
To learn more about Healthwise, visit Healthwise.org.
© 1995-2018 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Disclaimer: The information contained in this website, and its associated websites, is provided as a benefit to the local community, and the Internet community in general; it does not constitute medical advice. We try to provide quality information, but we make no claims, promises or guarantees about the accuracy, completeness, or adequacy of the information contained in or linked to this website and its associated sites. As medical advice must be tailored to the specific circumstances of each patient and healthcare is constantly changing, nothing provided herein should be used as a substitute for the advice of a competent physician. Furthermore, in providing this service, Adventist HealthCare does not condone or support all of the content covered in this site. As an Adventist health care organization, Adventist HealthCare acts in accordance with the ethical and religious directives for Adventist health care services.
Find an Adventist HealthCare affiliated doctor by calling our FREE physician referral service at 800-642-0101 or by searching our online physician directory.
Set Your Location
Setting your location helps us to show you nearby providers and locations based on your healthcare needs.