Pronunciation: AL vi MOE pan

Brand: Entereg

What is the most important information I should know about alvimopan?

You should not use alvimopan if you have severe liver or kidney disease, or if you have used an opioid medicine for more than 7 days in a row just before your surgery.

Some people had heart attacks while taking alvimopan long-term during clinical studies. It is not clear whether alvimopan is the actual cause of heart attack. This medicine should not be used for longer than 7 days after your surgery.

What is alvimopan?

Alvimopan reduces certain side effects of opioid medicine used to prevent pain after surgery. Some side effects of opioid medicine (stomach pain, bloating, constipation) can delay recovery after surgery on your stomach or intestines.

Alvimopan will not reduce the pain-relieving effects of the opioid.

Alvimopan is also used to help restore normal digestive functioning after surgery to remove a portion of your intestine.

Alvimopan is available only under a special program, and you will receive only 15 doses. You must be registered in the program and understand the risks and benefits of alvimopan.

Alvimopan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before I receive alvimopan?

You should not use alvimopan if you have severe liver or kidney disease.

Do not take alvimopan if you have used opioid medicine for more than 7 days in a row just before your intestinal surgery. Opioid medicines include codeine, fentanyl, hydrocodone, meperidine, methadone, morphine, oxycodone, and many others.

Tell your doctor if you have ever had:

  • liver or kidney disease;
  • heart disease or prior heart attack;
  • blockage in your digestive tract (stomach or intestines);
  • a colostomy or ileostomy;
  • a pancreas disorder; or
  • if you have recently used any type of opioid medicine.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How is alvimopan given?

Alvimopan is given only in a hospital for a short period of time.

You will receive your first dose of alvimopan before your surgery. You will then be given additional doses 2 times per day for up to 7 days.

This medicine should not be used for longer than 7 days after your surgery.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving alvimopan?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of alvimopan?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some people had heart attacks while taking alvimopan long-term. It is not clear whether alvimopan is the actual cause of a heart attack. Call your doctor at once if you have heart attack symptoms, such as:

  • chest pain or pressure;
  • pain spreading to your jaw or shoulder;
  • anxiety, nausea, sweating.

Common side effect may include indigestion.

You may be more likely to have unpleasant effects on your stomach if you used any type of opioid medicine shortly before your surgery.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect alvimopan?

Other drugs may affect alvimopan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

It is especially important to tell your doctor if you have used opioid medicine within the past 7 days. Opioid medicine is usually given to treat moderate to severe pain. Some prescription cough medications also contain opioids.

Where can I get more information?

Your doctor or pharmacist can provide more information about alvimopan

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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