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Home > Living Well > Health Library > Diphenhydramine-PE-DM Tannates
Antihistamines, including diphenhydramine, can cause "anticholinergic" side effects such as dryness of mouth and heart palpitations. Henbane (Hyoscyamus niger) also has anticholinergic activity and side effects. Therefore, use with diphenhydramine could increase the risk of anticholinergic side effects, though apparently no interactions have yet been reported with diphenhydramine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.
Last Review: 03-24-2015
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