What Are Star Ratings?
Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by some in the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 StarsReliable and relatively consistent scientific data showing a substantial health benefit.
2 StarsContradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 StarFor an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
| Supplement |
Why |
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3 Stars
Niacinamide (Vitamin B3)
Apply 4% gel twice per day
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In a double-blind trial, applying a topical 4% niacinamide gel twice daily for two months significantly improved acne.
In a double-blind trial, topical application of a 4% niacinamide gel twice daily for two months resulted in significant in improvement in people with acne. However, there is little reason to believe this vitamin would have similar actions if taken orally. |
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3 Stars
Tea Tree
Apply 5% oil twice per day
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Although tea tree oil is slower and less potent than benzoyl peroxide, it has been shown to improve acne with far fewer side effects.
A clinical trial compared the topical use of 5% tea tree oil to 5% benzoyl peroxide for common acne. Although the tea tree oil was slower and less potent in its action, it had far fewer side effects and was thus considered more effective overall.The effectiveness of tea tree oil was confirmed in a six-week double-blind trial. In that study, participants applied a 5% tea tree oil gel to the affected area twice a day for 20 minutes and then washed it off with tap water.
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3 Stars
Zinc
60 to 90 mg daily
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Several double-blind trials indicate that taking zinc reduces acne severity. Long-term use requires 1 to 2 mg of copper per day to prevent copper deficiency.
Several double-blind trials indicate that zinc supplements reduce the severity of acne. In one double-blind trial, though not in another, zinc was found to be as effective as oral antibiotic therapy. Doctors sometimes suggest that people with acne take 30 mg of zinc two or three times per day for a few months, then 30 mg per day thereafter. It often takes 12 weeks before any improvement is seen. Long-term zinc supplementation requires 1–2 mg of copper per day to prevent copper deficiency.
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2 Stars
Guggul
500 mg extract twice per day
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A controlled trial found that guggul (Commiphora mukul) compared favorably to tetracycline in treating cystic acne.
One controlled trial found that guggul (Commiphora mukul) compared favorably to tetracycline in the treatment of cystic acne. The amount of guggul extract taken in the trial was 500 mg twice per day.
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1 Star
Burdock
Refer to label instructions
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Tonic herbs such as burdock are believed to have a cleansing action when taken internally and have been used historically to treat skin conditions.
Historically, tonic herbs, such as burdock, have been used in the treatment of skin conditions. These herbs are believed to have a cleansing action when taken internally. Burdock root tincture may be taken in the amount of 2 to 4 ml per day. Dried root preparations in a capsule or tablet can be used at 1 to 2 grams three times per day. Many herbal preparations combine burdock root with other alterative herbs, such as yellow dock, red clover, or cleavers. In the treatment of acne, none of these herbs has been studied in scientific research.
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1 Star
Pantothenic Acid
Refer to label instructions
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In a preliminary trial, taking panthothenic acid supplements and applying a topical cream improved moderate acne in two months and severe acne within six months.
In a preliminary trial, people with acne were given 2.5 grams of pantothenic acid orally four times per day, for a total of 10 grams per day—a remarkably high amount. A cream containing 20% pantothenic acid was also applied topically four to six times per day. With moderate acne, near-complete relief was seen within two months, while severe conditions took at least six months to respond. Eventually, the intake of pantothenic acid was reduced to 1 to 5 grams per day—still a very high amount.
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1 Star
Vitamin A
Refer to label instructions
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Under medical supervision, large quantities of vitamin A have been used successfully to treat severe acne. However, the acne typically returns after treatment is discontinued.
Large quantities of vitamin A—such as 300,000 IU per day for females and 400,000–500,000 IU per day for males—have been used successfully to treat severe acne. However, unlike the long-lasting benefits of the synthetic prescription version of vitamin A (isotretinoin as Accutane), the acne typically returns several months after natural vitamin A is discontinued. In addition, the large amounts of vitamin A needed to control acne can be toxic and should be used only under careful medical supervision.
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1 Star
Vitamin B6
Refer to label instructions
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While not proven in research, some reports suggest that it may alleviate adolescent and premenstrual acne, however, another report has suggested that it might make acne worse.
A preliminary report suggested that vitamin B6 at 50 mg per day may alleviate premenstrual flare-ups of acne experienced by some women. While no controlled research has evaluated this possibility, an older controlled trial of resistant adolescent acne found that 50–250 mg per day decreased skin oiliness and improved acne in 75% of the participants. However, another preliminary report suggested that vitamin B6 supplements might exacerbate acne vulgaris.
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1 Star
Vitex (Premenstruation)
Refer to label instructions
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Some older, preliminary research suggests that vitex might help clear premenstrual acne, possibly by regulating hormonal influences.
Some older, preliminary German research suggests that vitex might contribute to clearing of premenstrual acne, possibly by regulating hormonal influences on acne. Women in these studies used 40 drops of a concentrated liquid product once daily. |
