Drug Information

Clopidogrel is used to prevent a second heart attack or stroke in people with atherosclerosis, and is known as an anti-platelet drug. At the time of this writing, no evidence of nutrient or herb interactions involving clopidogrel was found in the medical literature.

Common brand names:


Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions:BeneficialAdverseCheck

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Dan shen (Salvia miltiorrhiza), a Chinese herb, was associated with increased warfarin activity in two cases. Although warfarin acts differently from ticlopidine, both affect parameters of bleeding. Until more is known, people taking ticlopidine should use dan shen only under close medical supervision. Sage (Salvia officinalis), a plant relative of dan shen found in the West, has not been not associated with interactions involving warfarin.

  • Eleuthero

    Ginseng (Panax ginseng) was associated with a decrease in warfarin activity in a case study. This report suggests that ginseng may affect parameters of bleeding. Therefore, people taking ticlopidine should consult with a physician knowledgeable about botanical medicines before taking Asian ginseng or eleuthero/Siberian ginseng (Eleutherococcus senticosus).

  • Reishi

    As it may increase bleeding time, reishi (Ganoderma lucidum) is not recommended for those taking anticoagulant (blood-thinning) medications.

Explanation Required 

  • Bromelain

    In theory, bromelain might enhance the action of anticoagulants. This theoretical concern has not been substantiated by human research, however.

  • Ginger

    Ginger has been shown to reduce platelet stickiness in test tubes. Although there appear to be no reports of interactions with platelet inhibiting drugs, people should talk with a healthcare professional if they are taking a platelet inhibitor and wish to use ginger.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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