Reishi

Uses

Botanical names:
Ganoderma lucidum

Parts Used & Where Grown

Reishi mushrooms grow wild on decaying logs and tree stumps in the coastal provinces of China. The fruiting body of the mushroom is employed medicinally. Reishi grows in six different colors, but the red variety is most commonly used and commercially cultivated in North America, China, Taiwan, Japan, and Korea.1

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
Benign Prostatic Hyperplasia
6 mg per day for 8 weeks
A double-blind trial found that an extract of Ganoderma lucidum mushroom was significantly more effective than a placebo in improving urinary symptoms in men with BPH.
In a double-blind trial, an extract of Reishi mushroom (Ganoderma lucidum; 6 mg per day for 8 weeks) was significantly more effective than a placebo in improving urinary symptoms in men with BPH. Reishi extract appears to work by inhibiting 5-alpha-reductase, the enzyme that converts testosterone to its more active form, dihydrotestosterone (DHT).
1 Star
Altitude Sickness
Refer to label instructions
Reishi has been reported to be a helpful treatment for altitude sickness but this use still needs to be confirmed in well-designed human trials.
While human research has been reported that demonstrates some efficacy for the herb in treating altitude sickness and chronic hepatitis B, these uses still need to be confirmed in well-designed human trials.
1 Star
Hepatitis
Take zinc L-carnosine supplying 17 mg zinc twice daily
The mushroom reishi appears to be effective in treating chronic hepatitis B, according to preliminary research.

Preliminary human research demonstrates some efficacy for the mushroom in treating chronic hepatitis B; however, additional clinical trials are needed.
1 Star
HIV and AIDS Support
Refer to label instructions
Reishi is medicinal mushroom with immune-modulating effects that may be beneficial for people with HIV infection.

Immune-modulating plants that could theoretically be beneficial for people with HIV infection include Asian ginseng, eleuthero, and the medicinal mushrooms shiitake and . One preliminary study found that steamed then dried Asian ginseng (also known as red ginseng) had beneficial effects in people infected with HIV, and increased the effectiveness of the anti-HIV drug, AZT. This supports the idea that immuno-modulating herbs could benefit people with HIV infection, though more research is needed.
1 Star
Hypertension
165 mg per day of a 25:1 concentrated extract
Reishi mushroom has anti-inflammatory and antioxidant effects, but clinical trials have not consistently shown it can lower blood pressure.
Reishi (Ganoderma lucidum) is a medicinal mushroom used mainly for its anti-stress and immune-modulating effects. Both the fruiting body and mycelium have been shown to contain biologically-active peptides (short amino acid chains) that may lower blood pressure. In a placebo-controlled trial that enrolled 26 subjects with borderline-high blood pressure and/or cholesterol levels, those given 1.44 grams of reishi per day for 12 weeks had improvements in some metabolic parameters, but no changes in blood pressure were noted. Another placebo controlled trial with 84 participants found 3 grams of reishi per day for 16 weeks had no impact on aspects of metabolic syndrome, including high blood pressure. One trial, however, reported that mushrooms significantly lowered blood pressure in humans. The trial used a concentrated extract of reishi (25:1) in the amount of 55 mg three times per day for four weeks.
1 Star
Infection
Refer to label instructions
Reishi supports the immune system in the fight against microbes.

Herbs that support a person’s immune system in the fight against microbes include the following: American ginseng, andrographis, Asian ginseng, astragalus, coriolus, eleuthero, ligustrum, maitake, picrorhiza, , schisandra, and shiitake.
1 Star
Type 1 Diabetes
Refer to label instructions
Reishi may improve immune function and has demonstrated benefits in diabetic animals.
Animal studies suggest reishi extract may improve immune function and wound healing in the context of type 1 diabetes. Furthermore, reishi has demonstrated anti-diabetic actions, such as lowering high glucose levels and increasing insulin levels, in animal studies. Clinical trials are needed to confirm these effects in humans.
1 Star
Type 2 Diabetes
Refer to label instructions
Reishi may have some beneficial action in people with diabetes.
Multiple studies using experimental and animal models of type 2 diabetes have reported anti-diabetes effects of reishi mushroom (Ganoderma lucidum) and its constituents. However, in a placebo-controlled trial with 84 participants, 3 grams per day of reishi mushroom for 16 weeks had no effect on glycemic control or any metabolic markers in people with type 2 diabetes.

Traditional Use (May Not Be Supported by Scientific Studies)

Reishi has been used in Traditional Chinese Medicine for at least 2,000 years.2 The Chinese name ling zhi translates as the “herb of spiritual potency” and was highly prized as an elixir of immortality.3 Its Traditional Chinese Medicine indications include treatment of general fatigue and weakness, asthma, insomnia, and cough.4

How It Works

Botanical names:
Ganoderma lucidum

How It Works

Reishi contains several major constituents, including sterols, coumarin, mannitol, polysaccharides, and triterpenoids called ganoderic acids. Ganoderic acids may lower blood pressure as well as decrease LDL (“bad”) cholesterol. These specific triterpenoids also help reduce blood platelets from sticking together—an important factor in lowering the risk for coronary artery disease. While human research has been reported that demonstrates some efficacy for the herb in treating altitude sickness and chronic hepatitis B, these uses still need to be confirmed in well-designed human trials.5 Animal studies and some very preliminary trials in humans suggest reishi may have some beneficial action in people with diabetes mellitus and cancer.6 Two controlled clinical trials have investigated the effects of reishi on high blood pressure in humans and both found it could lower blood pressure significantly compared to a placebo or controls.7, 8 The people with hypertension in the second study had previously not responded to medications, though these were continued during the study.

How to Use It

Reishi can be taken either as 1.5–9 grams per day of the crude dried mushroom, 1–1.5 grams per day in powdered form, 1 ml per day of tincture, or as a tea.9

Interactions

Botanical names:
Ganoderma lucidum

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

Certain medicines interact with this supplement.

What Are Drug Interactions
Types of interactions:BeneficialAdverseCheck

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Clopidogrel

    As it may increase bleeding time, reishi (Ganoderma lucidum) is not recommended for those taking anticoagulant (blood-thinning) medications.

  • Dipyridamole

    As it may increase bleeding time, reishi (Ganoderma lucidum) is not recommended for those taking anticoagulant (blood-thinning) medications.

  • Heparin

    As it may increase bleeding time, reishi (Ganoderma lucidum) is not recommended for those taking anticoagulant (blood-thinning) medications.

  • Ticlopidine

    As it may increase bleeding time, reishi (Ganoderma lucidum) is not recommended for those taking anticoagulant (blood-thinning) medications.

Explanation Required

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Botanical names:
Ganoderma lucidum

Side Effects

Side effects from reishi can include dizziness, dry mouth and throat, nosebleeds, and abdominal upset. These rare effects may develop with continuous use over three to six months.10Pregnant or breast-feeding women should consult a physician before taking reishi.

References

1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 255-60.

2. Jones K. Reishi: Ancient Herb for Modern Times. Issaquah, WA: Sylvan Press, 1990, 6.

3. Willard T. Reishi Mushroom: Herb of Spiritual Potency and Wonder. Issaquah, WA: Sylvan Press, 1990, 11.

4. Shu HY. Oriental Materia Medica: A Concise Guide. Palos Verdes, CA: Oriental Healing Arts Press, 1986, 640-1.

5. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96-107.

6. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256-66 [review].

7. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531-3.

8. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.

9. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96-107.

10. McGuffin M, Hobbs C, Upton R, Goldberg A (eds). American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997, 55.

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